Non‐Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer‐Aided Drug Design
نویسندگان
چکیده
منابع مشابه
Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase. Serendipitously, we also found that several predicted farnesyl diphosphate synthase inhibitors were low-micromolar inhibitors of undecaprenyl diphosphate synthase. These results are of in...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2011
ISSN: 1747-0277,1747-0285
DOI: 10.1111/j.1747-0285.2011.01164.x